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Traveling the Lower Mississippi with American Cruise Lines is an experience like no other. Our carefully selected onboard experts bring the history and culture of this region to life with award-winning enrichment programs.

Enjoy customized excursions from iconic ports in Oak Alley and Natchez where you gain an insiders’ perspective of classic antebellum homes and renowned plantations. Delve deep into the history of the Civil War in Vicksburg as an American Cruise Line historian leads you through the National Military Park commemorating the campaign, siege, and defense of this city.

As music is synonymous with the Mississippi River, our highly acclaimed onboard performers will entertain you throughout the voyage. In the evenings, relax in comfort on your private balcony as you take in the spectacular rolling river views.

Ask about our Current Savings and our Complimentary Pre-Cruise Packages which include a premium hotel stay, city tour, and transportation to the ship. See the day by day itinerary tab below.

Image Courtesy American Cruise Lines

New! 3 Ships to choose from: Queen of the Mississippi Paddlewheeler and the new American Harmony and America.

The American River Cruise revolution continues with American Harmony, the newest ship in American Cruise Lines’ highly anticipated series of contemporary riverboats. These, the first modern riverboats ever in the U.S., have introduced many pioneering innovations to America’s waters.

American Harmony will continue American Cruise Lines’ decade’s long tradition for innovation in river cruising. With a capacity of just 190 guests, this new ship has the modern design features and contemporary styling that today’s traveler has come to expect.

Featured will be lounges soaring 40 feet above the water as well as triple the glass of other riverboats, offering astounding views. The new riverboat will also feature the Atrium, a four-story glass-enclosed area with a large domed skylight, which will serve as the central gathering point for the entire ship.

Our new suite design will allow for unprecedented comfort while traveling, beginning with the new Grand Suites featuring 800 square feet of private space. These spacious suites include two glass walls and a wraparound private balcony. Complimentary room service during select mealtimes is available for every stateroom, but the Grand Suites offer ample space to host small cocktail parties or private dinner events.


    Call for Stateroom Availability & PricingPRICING LAND ONLY
    (based on double occupancy)*
    Cruise Package from category A (fixed window)$3,995* **
    Cruise Package from category AAR (private balcony)$4,910* **
    Port charges$250
    Travel ProtectionCall for quote
    Final balance due120 days before departure
    * Call for single supplement and for other stateroom categories.
    ** Cruise price varies by ship, date and itinerary selected

    Cancellation policy: if travel protection is not purchased, cancellation charges will be assessed as follows: cancellation charges are per-person, based on the cancellation date, as follows:
    (i) up to 120 days before departure: 100% refund, less $250 cancellation fee
    (ii) 119-90 days before departure: 50% penalty, less $250 cancellation fee;
    (iii) 89-0 days before departure: no refund.

    Cancellation charges also apply to additional charges for upgrades, transfers and other pre-purchased services. Protection plan premiums are non-refundable. Additional cancellation fees apply for air tickets. After travel begins, there is no refund for unused services, or unused portions of cruise or cruise/tour.

    • Operated by American Cruise Lines
    • Home pick-up/return Indy metro area
    • Deluxe hotel stay before your voyage: includes breakfast, taxes, porterage and transfers to your ship
    • Complimentary shore excursions everyday
    • All gourmet meals
    • Cocktail hour for all guests
    • Premium bed and bath amenities
    • WiFi throughout the ship
    • Lounges, library and card room
    • Spacious sun deck
    • All-American built ships
    • Daily entertainment
    • All on board gratuities
    Our Lower Mississippi Itinerary offers two Pre-Cruise Package options, providing you with a seamless way to board the ship and explore the local area.

    Pre-Cruise: Hotel Stay – Memphis, TN
    2- Night Graceland Premium Pre-Cruise Package
    Any trip to Memphis is not complete without visiting Graceland to explore the home of the King. This unique pre-cruise experience at Elvis’ home includes a 2-night stay at the Graceland Guest House with Ultimate VIP Pass & Tour. You’ll tour the museum dedicated to Elvis’ career, his famous car collection, his custom jets, and of course, his mansion, with an expert guide. On the morning of the cruise we will meet you in the lobby of the hotel to bring you to the ship for an easy boarding process. There is limited availability for this package, so please inquire when making your cruise reservation.

    1-Night Complimentary Pre-Cruise Package
    Arrive the day before your scheduled cruise date and American Cruise Lines will handle the rest. Enjoy a 1-night premium hotel stay in the heart of downtown, within walking distance to shops, theatres, and restaurants, where you can explore the city at your leisure. On the morning of the cruise, meet in the hotel lobby after breakfast and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.

    Day 1: Memphis, TN
    Welcome to Memphis! Home to Blues, BBQ, Beale Street, and of course, the King of Rock ‘n Roll – Elvis Presley. This amazing city is the perfect place to begin your Mississippi River Voyage. Come a day or two early and immerse yourself in sights, sounds, and tastes of this exciting destination.

    Day 2: Day of River Cruising
    Bask in the warmth of the Mississippi River sun as we cruise from Memphis to Vicksburg. Relax in one of the many spacious lounges or enjoy a gentle breeze on the sun deck.

    Day 3: Vicksburg, MS
    The city of Vicksburg served as a pivotal turning point during the American Civil War. Come with us as our informative historian leads us through the National Military Park, commemorating the campaign, siege, and defense of Vicksburg. Our expert guides and park rangers will take you to battlefields, the U.S.S. Cairo gunboat, and the most significant historic places.

    Complimentary Excursions include:
    Vicksburg National Military Park
    Anchuca Historic Mansion
    Historic Vicksburg Comes to Life

    Day 4: Natches, MS
    Settled in 1716, Natchez is rich in history and southern hospitality. Enjoy a guided exploration of this fascinating city which has retained its antebellum charm since its surrender during the Civil War. Visit Frogmore, a historic cotton plantation still in use today, or attend a special piano concert in the J. N. Stone antebellum music room.

    Complimentary Excursions include:
    Historic Longwood Exploration
    Frogmore Plantation
    J.N. Stone House Tour & Concert
    Natchez Shuttle

    Day 5: St. Francisville, LA
    This southern town charms with simple pleasures and unique treasures. Located on the bluffs of the Mississippi River, St. Francisville has been called, “One of the 200 most beautiful small towns in America.” Take a stroll through its historic center where two centuries of architecture and lifestyle are on display. Enjoy visits to restored antebellum mansions including Rosedown.

    Complimentary Excursion includes:
    Rosedown Plantation

    Day 6: Baton Rouge, LA
    Baton Rouge features all the history and wonder you would expect in a state capital, but with an added down-home flavor that makes it truly unique. Our local expert guides will take you on a tour of the cities’ most famous attractions including the Old and New State Capitols and the interactive Louisiana State Museum.

    Complimentary Excursions include:
    USS Kidd
    Historic Baton Rouge Exploration

    Signature Tour at additional cost:
    Atchafalaya Basin Excursion

    Day 7: Oak Alley, LA
    Once serving as an antebellum sugar cane homestead, Oak Alley Plantation is named after its most distinguishing feature, a row of 300-year-old oak trees. This leafy canopy forms a path leading to the Mississippi River. Restored to its 19th-century grandeur, this classic Greek Revival antebellum mansion is simply breathtaking.

    Complimentary Excursions includes:
    Oak Alley Plantation

    Day 8: New Orleans, LA
    End your journey in the vibrant city of New Orleans, also known as the Big Easy, where art and culture abound. The open-air artist colony proudly displays local works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve its rich history. Stay an extra day or even a few nights to enjoy the famed French Quarter.

    Complimentary Excursion includes:
    New Orleans City Excursion (only available for cruises ending in New Orleans)

  • Image Courtesy American Cruise Lines

    Image Courtesy American Cruise Lines

    Image Courtesy American Cruise Lines

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Call Interlude Tours today to book your Lower Mississippi River
Cruise-Tour! (317) 913-0387